Endocrine Abstracts

Selective transsphenoidal resection of the pituitary adenoma is the initial treatment of choice for Cushing disease. Although the achievement of low cortisol levels following transsphenoidal surgery for Cushing disease is associated with surgical success, recurrence can still occur.Case presentationA 38 years old female patient, known with Cushing disease, secondary hypertension, type 2 diabetes and osteopenia, is admitted to our c...

Case history: A 28 year-old male of British origin was referred with a one-year history of a left-sided chest mass and an abnormal chest X-ray. He was otherwise fit and well, had a past medical history of vitiligo and had no relevant family history. His physical examination revealed some hypopigmented spots on his skin, several tattoos across his back and a firm mass on his left upper chest, which was mildly tender on palpation. He had no other palpable masses.<p class="ab...

Case history: A 17 year old previously healthy male presented to his local emergency department with a generalised tonic seizure associated with severe hypertension (systolic blood pressure 240 mmHg) and tachycardia. He was intubated and admitted to the Intensive Care Unit. Antimicrobials to cover meningoencephalitis were commenced and his hypertension was managed with intravenous labetalol. He was extubated the following day. He had experienced headaches on a monthly basis fo...

Growth hormone (GH) is involved in body growth and metabolism. This hormone is used for the treatment of various clinical conditions and is administrated subcutaneously once daily or 3 times a week. The chronic use of GH has side effects; among them, the increase in tumor incidence. GH activates pathways related with oncogenesis not only by the activation of its specific receptor, but also by transactivation and regulation of the expression of the epidermal growth factor recep...

Introduction: The interaction between corticosteroids and protease inhibitors (PIs) is a clearly described drug interaction.Case report: A 44-year-old woman diagnosed with HIV category B3 diagnosed in 1989; severe lipodystrophy. In addition , HCV genotype IA. Bronchial asthma since 2000. Treatment with fluticasone 1 inh/24 h, salbutamol on demand, darunavir 800 mg/day and ritonavir 100 mg/day. He had known lipodystrophy since 2001 and the abdominal perim...

Pituitary apoplexy (PA) is a rare syndrome that requires urgent assistance. It is due to ischemia or hemorrhage of pituitary tissue, almost always inside a pituitary tumor. PA may be the first manifestation of a neuroendocrine tumor or occur during follow up.Objective: To describe the characteristics of patients with PA treated in the Department of Endocrinology and Nutrition in the last 10 years and study the presence of possible risk factors for it.</p...

Adrenocortical carcinoma (ACC) is a rare malignancy with an incidence of 0.7–2.0 cases/million habitants/year, often with a dismal prognosis. Patients present with abdominal symptoms or symptoms of hormone excess. However, 15% are diagnosed incidentally. (1) A 59y male was referred with progressive lethargy, weight loss, dyspepsia and abdominal distension over the past 2 years. He was dismissive of ‘the elephant in the room’ and in denial. He was pushed to seek ...

Epidemiological studies have shown that caffeine increases plasma SHBG levels and also reduce the risk of type 2 diabetes. There are no reports describing any molecular mechanism by which caffeine regulates hepatic SHBG production. The aim of the present study was to explore whether caffeine regulates SHBG production and to determine the associated molecular mechanisms. For this purpose, in vitro and in vivo studies were performed using human HepG2 cells and ...

Introduction: Although meningiomas often occurs in parasellar regions such as the tuberculum sellae, olfactory groove, and sphenoid wing, pure intrasellar meningiomas are extremely rare. Patients usually present with gradual visual deterioration secondary to compression of the optic apparatus. Obtaining a correct preoperative diagnosis will likely require a thorough clinical assessment including neuroimaging and endocrine studies.Case report: A 56 year-o...

Introduction: The caloric expenditure and thermogenesis are very important aspects in the obesity problem, mostly underestimated. The ‘Protein Leverage Hypothesis’ (PLH) promotes the effect of satiety, delaying the hunger sensation; thus entails the regulation of caloric intake and body weight, as well as, the modification of thermogenic activity and energy expenditure. However, the effect of high protein diet over the physiological components of energy expenditure h...